| Bioactivity | AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. | ||||||
| Invitro | The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome[1]. | ||||||
| Name | Fmoc-Thr[GalNAc(Ac)3-α-D]-OH | ||||||
| CAS | 116783-35-8 | ||||||
| Formula | C33H38N2O13 | ||||||
| Molar Mass | 670.66 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH
CAS: 116783-35-8 F: C33H38N2O13 W: 670.66
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
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